Open AccessCyperus spp.: A Review on Phytochemical Composition, Biological Activity, and Health-Promoting Effects
Author(s) -
Yasaman Taheri,
Jesús HerreraBravo,
Luis Huala,
Luis A. Salazar,
Javad SharifiRad,
Muhammad Akram,
Khuram Shahzad,
Guiomar MelgarLalanne,
Navid Baghalpour,
Katayoun Tamimi,
Javad Mahroo-Bakhtiyari,
Dorota Kręgiel,
Abhijit Dey,
Manoj Kumar,
Hafiz Ansar Rasul Suleria,
Natália CruzMartins,
William C. Cho
Publication year - 2021
Publication title -
oxidative medicine and cellular longevity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.494
H-Index - 93
eISSN - 1942-0900
pISSN - 1942-0994
DOI - 10.1155/2021/4014867
Subject(s) - cyperus , cyperus rotundus , cyperaceae , phytochemical , biology , traditional medicine , medicine , botany , poaceae
Cyperaceae are a plant family of grass-like monocots, comprising 5600 species with a cosmopolitan distribution in temperate and tropical regions. Phytochemically, Cyperus is one of the most promising health supplementing genera of the Cyperaceae family, housing ≈950 species, with Cyperus rotundus L. being the most reported species in pharmacological studies. The traditional uses of Cyperus spp. have been reported against various diseases, viz. , gastrointestinal and respiratory affections, blood disorders, menstrual irregularities, and inflammatory diseases. Cyperus spp. are known to contain a plethora of bioactive compounds such as α -cyperone, α -corymbolol, α -pinene, caryophyllene oxide, cyperotundone, germacrene D, mustakone, and zierone, which impart pharmacological properties to its extract. Therefore, Cyperus sp. extracts were preclinically studied and reported to possess antioxidant, anti-inflammatory, antimicrobial, anticancer, neuroprotective, antidepressive, antiarthritic, antiobesity, vasodilator, spasmolytic, bronchodilator, and estrogenic biofunctionalities. Nonetheless, conclusive evidence is still sparse regarding its clinical applications on human diseases. Further studies focused on toxicity data and risk assessment are needed to elucidate its safe and effective application. Moreover, detailed structure-activity studies also need time to explore the candidature of Cyperus -derived phytochemicals as upcoming drugs in pharmaceuticals.