Open AccessProtective Effect of Opuntia dillenii (Ker Gawl.) Haw. Seed Oil on Gentamicin-Induced Nephrotoxicity: A Biochemical and Histological Analysis
Author(s) -
Mohamed Bouhrim,
Noureddine Bencheikh,
Hamada Imtara,
Nour Elhouda Daoudi,
Hamza Mechchate,
Hayat Ouassou,
Loubna Kharchoufa,
Mostafa Elachouri,
Hassane Mekhfi,
Abderrahim Ziyyat,
Abdelkhaleq Legssyer,
Mohammed Aziz,
Mohamed Bnouham
Publication year - 2021
Publication title -
the scientific world journal/thescientificworldjournal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.453
H-Index - 93
eISSN - 2356-6140
pISSN - 1537-744X
DOI - 10.1155/2021/2173012
Subject(s) - nephrotoxicity , gentamicin , creatinine , renal function , intraperitoneal injection , kidney , distilled water , medicine , toxicity , pharmacology , urea , traditional medicine , chemistry , antibiotics , biochemistry , chromatography
Opuntia dillenii is a medicinal plant with frequent usage in folk medicine to treat many illnesses. The present study aims to investigate the protective effect of Opuntia dillenii seed oil against gentamicin-induced nephrotoxicity in rats. The animals (rats) were randomly divided into three groups (i) the normal control group treated only with distilled water (10 mL/kg), (ii) the gentamicin group treated with distilled water (10 mL/kg) and received an intraperitoneal injection of gentamicin (80 mg/kg), and (iii) the group treated with the Opuntia dillenii seed oil (2 mL/kg) and also received an intraperitoneal injection of gentamicin (80 mg/kg). The rats received their following treatments for 14 consecutive days orally. Serum urea, creatinine, gamma-glutamyl transferase, albumin, and electrolyte levels were quantified as the markers of acute renal and liver failure. Besides, the kidney and liver relative weight, kidney malondialdehydes, and kidney histological analysis were determined. The results have shown that daily pretreatment with Opuntia dillenii seed oil (2 mL/kg) prevented severe alterations of biochemical parameters and disruptions of kidney tissue structures. In addition, the results of the present study showed for the first time that Opuntia dillenii seed oil reduced renal toxicity in gentamicin-induced nephrotoxicity in rats. Therefore, Opuntia dillenii seed oil may represent a new therapeutic avenue to preserve and protect renal function in gentamicin-treated patients.