Open AccessThe Preventive Effects of Asparagus officinalis Extract on Sodium Selenite-Induced Cataractogenesis in Experimental Animal Models
Author(s) -
M Azadbakht,
Mohammad Asghari,
Kiumars Nowroozpoor Dailami,
Ali Davoodi,
Amirhossein Ahmadi
Publication year - 2020
Publication title -
evidence-based complementary and alternative medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.552
H-Index - 90
eISSN - 1741-4288
pISSN - 1741-427X
DOI - 10.1155/2020/3708730
Subject(s) - asparagus , malondialdehyde , medicine , officinalis , selenium , lipid peroxidation , oxidative stress , glutathione , cataract surgery , antioxidant , cataracts , pharmacology , chemistry , surgery , traditional medicine , ophthalmology , biochemistry , botany , biology , organic chemistry , enzyme
Materials and Methods Neonatal rats received a single dose of sodium selenite as an intraperitoneal injection (30 μ mol/kg) on day 10 postnatal to induce cataract. Animals were then posttreated with various oral solutions of A. officinalis extract at 200 mg/kg or 400 mg/kg once daily on days 10–16 postnatal. Cataract was evaluated by slit-lamp, and lens opacification was analyzed in each group 24 hours after the last treatment at day seven postadministration of the extracts or vehicle. The total protein concentration of lenses, glutathione reductase activity as the glutathione antioxidant capacity, and malondialdehyde content as a marker of lipid peroxidation were further assessed in removed rat lenses on day 30 postnatal.Results All lenses in the healthy and control plant groups were clear. Sodium selenite significantly increased cataract grade (2.8 ± 0.2) when compared to the healthy group ( p = 0.001). However, cataract grades were decreased considerably as 1.9 ± 0.72 and 1.5 ± 0.85 in groups that received 200 mg/kg and 400 mg/kg oral extract of A. officinalis , respectively. A. officinalis extract also restored all abnormalities of biochemical markers induced by sodium selenite.Conclusion Our data suggest that A. officinalis could be a promising candidate as a safe alternative treatment in cataracts upon further clinical trials. This effect is probably associated with the antioxidant activity of A. officinalis .