Open AccessClinical and Preclinical Systematic Review of Astragalus Membranaceus for Viral Myocarditis
Author(s) -
Qun Zheng,
Zhuang Zhuang,
Zi-Hao Wang,
Lihui Deng,
Wang-Jun Jin,
Zhihui Huang,
Guo-Qing Zheng,
Yan Wang
Publication year - 2020
Publication title -
oxidative medicine and cellular longevity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.494
H-Index - 93
eISSN - 1942-0900
pISSN - 1942-0994
DOI - 10.1155/2020/1560353
Subject(s) - checklist , astragalus , placebo , medicine , incidence (geometry) , troponin , clinical trial , myocarditis , adverse effect , troponin i , cardiology , biology , pathology , traditional chinese medicine , mathematics , alternative medicine , paleontology , geometry , myocardial infarction
Astragalus membranaceus (AM) is a traditional Chinese medicine, which possesses a variety of biological activities in the cardiovascular systems. We conducted a clinical and preclinical systematic review of 28 randomized clinical control studies with 2522 participants and 16 animal studies with 634 animals to evaluate the efficacy, safety, and possible mechanisms of AM for viral myocarditis (VM). The search strategies were performed in 7 databases from inception to January 2020. Application of the Cochrane Collaboration's tool 7-item checklist, SYRCLE's tool 10-item checklist, and Rev-Man 5.3 software to analyze the risk of bias of studies and data. The results show the score of clinical study quality ranged from 3 to 7 points with an average of 3.32, and the score of animal study quality ranged from 2 to 5 points with an average of 3. In clinical study, AM significantly reduced serum myocardial enzymes and cardiac troponin I levels and improved the clinical treatment efficiency in VM patients compared with the control group ( P < 0.05). There was no significant difference in the incidence of adverse reactions ( P > 0.05). Significant increase of the survival rate and decrease of the cardiac cardiology score, cardiac enzymes, and cardiac troponin I were compared with the placebo group in animal studies ( P < 0.05). The possible mechanisms of AM are largely through antivirus and antivirus receptors, anti-inflammatory, antioxidation, antiapoptotic, antifibrosis, and reducing cardiac calcium load. In conclusion, the findings suggested that AM is a cardioprotection candidate drug for VM.