Nanoprodrugs of NSAIDs Inhibit the Growth of U87-MG Glioma Cells | Zendy

BongSeop Lee | Zendy; Xiangpeng Yuan | Zendy; Qijin Xu | Zendy; MinHee K. Ko | Zendy; Aruna K. Nalla | Zendy; Ilana Frankiel | Zendy; Talia C. Shear | Zendy; Keith L. Black | Zendy; John S. Yu | Zendy

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Nanoprodrugs of NSAIDs Inhibit the Growth of U87-MG Glioma Cells

Author(s) -

BongSeop Lee,

Xiangpeng Yuan,

Qijin Xu,

MinHee K. Ko,

Aruna K. Nalla,

Ilana Frankiel,

Talia C. Shear,

Keith L. Black,

John S. Yu

Publication year - 2010

Publication title -

journal of nanomaterials

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.463

H-Index - 66

eISSN - 1687-4129

pISSN - 1687-4110

DOI - 10.1155/2010/583970

Subject(s) - ibuprofen , naproxen , propidium iodide , prodrug , cell growth , pharmacology , apoptosis , reagent , nonsteroidal , glioma , cell , cancer research , chemistry , medicine , biochemistry , programmed cell death , organic chemistry , alternative medicine , pathology

Several recent reports have demonstrated that nonsteroidal anti-inflammatory drugs (NSAIDs) inhibit the growth of various malignant cells suggesting their application as anticancer agents. In this study, we prepared six nanometer-sized prodrugs (nanoprodrugs) of NSAIDs, ibuprofen, indomethacin, and naproxen through the spontaneous emulsification mechanism using monomeric and dimeric derivatives of the NSAIDs. We evaluated their effect on the proliferation of U87-MG glioma cells by cell counting, WST-1 cell proliferation reagent, and propidium iodide incorporation. The two ibuprofen nanoprodrugs inhibited the cell growth more potently than the indomethacin nanoprodrugs, whereas the naproxen nanoprodrugs did not show any significant effect. Remarkably, ibuprofen did not show any effect at an equimolar concentration. Approximately, 4.4% of the ibuprofen nanoprodrugs was found in the cell, whereas no ibuprofen could be detected suggesting that the superior effect of the nanoprodrugs can be attributed to the efficient cellular uptake of the nanoprodrugs

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