Open AccessMicroRNAs in skin and wound healing
Author(s) -
Jaideep Banerjee,
Yuk Cheung Chan,
Chandan K. Sen
Publication year - 2011
Publication title -
physiological genomics/physiological genomics (print)
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.078
H-Index - 112
eISSN - 1531-2267
pISSN - 1094-8341
DOI - 10.1152/physiolgenomics.00157.2010
Subject(s) - microrna , biology , wound healing , translation (biology) , messenger rna , gene expression , regulation of gene expression , microbiology and biotechnology , rna , bioinformatics , gene , computational biology , genetics
MicroRNAs (miRNAs) are small endogenous RNA molecules ∼22 nt in length. miRNAs are capable of posttranscriptional gene regulation by binding to their target messenger RNAs (mRNAs), leading to mRNA degradation or suppression of translation. miRNAs have recently been shown to play pivotal roles in skin development and are linked to various skin pathologies, cancer, and wound healing. This review focuses on the role of miRNAs in cutaneous biology, the various methods of miRNA modulation, and the therapeutic opportunities in treatment of skin diseases and wound healing.