Caloric restriction in leptin deficiency does not correct myocardial steatosis: failure to normalize PPARα/PGC1α and thermogenic glycerolipid/fatty acid cycling | Zendy

J. Eduardo Rame | Zendy; Lili A. Barouch | Zendy; Michael N. Sack | Zendy; Edward G. Lynn | Zendy; Mones AbuAsab | Zendy; Maria Tsokos | Zendy; Steven J. Kern | Zendy; Jennifer J. Barb | Zendy; Peter J. Munson | Zendy; Marc K. Halushka | Zendy; Karen Miller | Zendy; Karen Fox-Talbot | Zendy; Jianhua Zhang | Zendy; Joshua M. Hare | Zendy; Michael A. Solomon | Zendy; Robert L. Danner | Zendy

Open Access

Caloric restriction in leptin deficiency does not correct myocardial steatosis: failure to normalize PPARα/PGC1α and thermogenic glycerolipid/fatty acid cycling

Author(s) -

J. Eduardo Rame,

Lili A. Barouch,

Michael N. Sack,

Edward G. Lynn,

Mones AbuAsab,

Maria Tsokos,

Steven J. Kern,

Jennifer J. Barb,

Peter J. Munson,

Marc K. Halushka,

Karen Miller,

Karen Fox-Talbot,

Jianhua Zhang,

Joshua M. Hare,

Michael A. Solomon,

Robert L. Danner

Publication year - 2011

Publication title -

physiological genomics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.078

H-Index - 112

eISSN - 1531-2267

pISSN - 1094-8341

DOI - 10.1152/physiolgenomics.00088.2010

Subject(s) - caloric theory , steatosis , biology , leptin , medicine , endocrinology , thermogenesis , beta oxidation , metabolism , obesity

Evidence supports an antilipotoxic role for leptin in preventing inappropriate peripheral tissue lipid deposition. Obese, leptin-deficient mice develop left ventricular (LV) hypertrophy and myocardial steatosis with increased apoptosis and decreased longevity. Here we investigated the cardiac effects of caloric restriction versus leptin repletion in obese leptin-deficient (ob/ob) mice.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research