Open AccessCaloric restriction in leptin deficiency does not correct myocardial steatosis: failure to normalize PPARα/PGC1α and thermogenic glycerolipid/fatty acid cycling
Author(s) -
J. Eduardo Rame,
Lili A. Barouch,
Michael N. Sack,
Edward G. Lynn,
Mones AbuAsab,
Maria Tsokos,
Steven J. Kern,
Jennifer Barb,
Peter J. Munson,
Marc K. Halushka,
Karen Miller,
Karen Fox-Talbot,
Jianhua Zhang,
Joshua M. Hare,
Michael A. Solomon,
Robert L. Danner
Publication year - 2011
Publication title -
physiological genomics/physiological genomics (print)
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.078
H-Index - 112
eISSN - 1531-2267
pISSN - 1094-8341
DOI - 10.1152/physiolgenomics.00088.2010
Subject(s) - caloric theory , steatosis , biology , leptin , medicine , endocrinology , thermogenesis , beta oxidation , metabolism , obesity
Evidence supports an antilipotoxic role for leptin in preventing inappropriate peripheral tissue lipid deposition. Obese, leptin-deficient mice develop left ventricular (LV) hypertrophy and myocardial steatosis with increased apoptosis and decreased longevity. Here we investigated the cardiac effects of caloric restriction versus leptin repletion in obese leptin-deficient (ob/ob) mice.