Open AccessSARS-CoV-2 transgressing LncRNAs uncovers the known unknowns
Author(s) -
Nidhi Shukla,
Anchita Prasad,
Uma Kanga,
Renuka Suravajhala,
Vinod Kumar Nigam,
P. B. Kavi Kishor,
Rathnagiri Polavarapu,
Gyaneshwer Chaubey,
Keshav K. Singh,
Prashanth Suravajhala
Publication year - 2021
Publication title -
physiological genomics/physiological genomics (print)
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.078
H-Index - 112
eISSN - 1531-2267
pISSN - 1094-8341
DOI - 10.1152/physiolgenomics.00075.2021
Subject(s) - pathogenesis , orfs , biology , viral pathogenesis , endocytosis , open reading frame , computational biology , virology , genetics , gene , virus , immunology , cell , viral replication , peptide sequence
SARS-CoV-2 harbors many known unknown regions in the form of hypothetical open reading frames (ORFs). Although the mechanisms underlying the disease pathogenesis are not clearly understood, molecules such as long noncoding RNAs (lncRNAs) play a key regulatory role in the viral pathogenesis from endocytosis. We asked whether or not the lncRNAs in the host are associated with the viral proteins and argue that lncRNA-mRNAs molecules related to viral infection may regulate SARS-CoV-2 pathogenesis. Toward the end of the perspective, we provide challenges and insights into investigating these transgression pathways.