Open AccessPeripheral and Central Glucose Sensing In Hypoglycemic Detection
Author(s) -
C. M. Donovan,
Alan G. Watts
Publication year - 2014
Publication title -
physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.14
H-Index - 125
eISSN - 1548-9213
pISSN - 1548-9221
DOI - 10.1152/physiol.00069.2013
Subject(s) - hypoglycemia , peripheral , sensory system , medicine , neuroscience , blood sugar regulation , peripheral blood , biology , insulin , endocrinology
Hypoglycemia poses a serious threat to the integrity of the brain, owing to its reliance on blood glucose as a fuel. Protecting against hypoglycemia is an extended network of glucose sensors located within the brain and in the periphery that serve to mediate responses restoring euglycemia, i.e., counterregulatory responses. This review examines the various glucose sensory loci involved in hypoglycemic detection, with a particular emphasis on peripheral glucose sensory loci and their contribution to hypoglycemic counterregulation.