Open AccessSympathetic Innervation of White Adipose Tissue: to Beige or Not to Beige?
Author(s) -
Heike Münzberg,
Z. Elizabeth Floyd,
Ji Suk Chang
Publication year - 2021
Publication title -
physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.14
H-Index - 125
eISSN - 1548-9213
pISSN - 1548-9221
DOI - 10.1152/physiol.00038.2020
Subject(s) - adipocyte , white adipose tissue , adipose tissue , biology , white (mutation) , sympathetic innervation , brown adipose tissue , metabolic regulation , endocrinology , medicine , microbiology and biotechnology , neuroscience , metabolism , genetics , gene
Obesity research progresses in understanding neuronal circuits and adipocyte biology to regulate metabolism. However, the interface of neuro-adipocyte interaction is less studied. We summarize the current knowledge of adipose tissue innervation and interaction with adipocytes and emphasize adipocyte transitions from white to brown adipocytes and vice versa. We further highlight emerging concepts for the differential neuronal regulation of brown/beige versus white adipocyte and the interdependence of both for metabolic regulation.