Open AccessMolecular Pathways and Therapies in Autosomal-Dominant Polycystic Kidney Disease
Author(s) -
Takamitsu Saigusa,
P. Darwin Bell
Publication year - 2015
Publication title -
physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.14
H-Index - 125
eISSN - 1548-9213
pISSN - 1548-9221
DOI - 10.1152/physiol.00032.2014
Subject(s) - autosomal dominant polycystic kidney disease , pathogenesis , polycystic kidney disease , cilium , disease , pkd1 , medicine , kidney , polycystic kidney , bioinformatics , kidney disease , biology , pathology , genetics
Autosomal-dominant polycystic kidney disease (ADPKD) is the most prevalent inherited renal disease, characterized by multiple cysts that can eventually lead to kidney failure. Studies investigating the role of primary cilia and polycystins have significantly advanced our understanding of the pathogenesis of PKD. This review will present clinical and basic aspects of ADPKD, review current concepts of PKD pathogenesis, evaluate potential therapeutic targets, and highlight challenges for future clinical studies.