Open AccessExercise, Neurotrophins, and Axon Regeneration in the PNS
Author(s) -
Arthur W. English,
Jennifer C. Wilhelm,
Patricia J. Ward
Publication year - 2014
Publication title -
physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.14
H-Index - 125
eISSN - 1548-9213
pISSN - 1548-9221
DOI - 10.1152/physiol.00028.2014
Subject(s) - neurotrophin , regeneration (biology) , neurotrophic factors , neuroscience , axon , androgen receptor , stimulation , brain derived neurotrophic factor , receptor , neuroprotection , nerve growth factor , hormone , medicine , biology , endocrinology , microbiology and biotechnology , prostate cancer , cancer
Electrical stimulation and exercise are treatments to enhance recovery from peripheral nerve injuries. Brain-derived neurotrophic factor and androgen receptor signaling are requirements for the effectiveness of these treatments. Increased neuronal activity is adequate to promote regeneration in injured nerves, but the dosing of activity and its relationship to neurotrophins and sex steroid hormones is less clear. Translation of these therapies will require principles associated with their cellular mechanisms.