Novel Protein Therapeutics Created Using the Elastin-Like Polypeptide Platform | Zendy

Gene L. Bidwell | Zendy

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Novel Protein Therapeutics Created Using the Elastin-Like Polypeptide Platform

Author(s) -

Gene L. Bidwell

Publication year - 2021

Publication title -

physiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.14

H-Index - 125

eISSN - 1548-9213

pISSN - 1548-9221

DOI - 10.1152/physiol.00026.2021

Subject(s) - drug delivery , elastin , drug , targeted drug delivery , fusion protein , chemistry , nanotechnology , drug carrier , computational biology , biophysics , materials science , biochemistry , biology , medicine , recombinant dna , pharmacology , pathology , gene

Elastin-like polypeptides (ELPs) are bioengineered proteins that have a unique physical property, a thermally triggered inverse phase transition, that can be exploited for drug delivery. ELP-fusion proteins can be used as soluble biologics, thermally targeted drug carriers, self-assembling nanoparticles, and slow-release drug depots. Because of their unique physical characteristics and versatility for delivery of nearly any type of therapeutic, ELP-based drug delivery systems represent a promising platform for biologics development.

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