Open AccessPlasma Membrane Repair: A Central Process for Maintaining Cellular Homeostasis
Author(s) -
Alisa D. Blazek,
Brian J. Paleo,
Noah Weisleder
Publication year - 2015
Publication title -
physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.14
H-Index - 125
eISSN - 1548-9213
pISSN - 1548-9221
DOI - 10.1152/physiol.00019.2015
Subject(s) - exocytosis , microbiology and biotechnology , endocytosis , homeostasis , membrane , cell membrane , biology , cell , chemistry , biochemistry
Plasma membrane repair is a conserved cellular response mediating active resealing of membrane disruptions to maintain homeostasis and prevent cell death and progression of multiple diseases. Cell membrane repair repurposes mechanisms from various cellular functions, including vesicle trafficking, exocytosis, and endocytosis, to mend the broken membrane. Recent studies increased our understanding of membrane repair by establishing the molecular machinery contributing to membrane resealing. Here, we review some of the key proteins linked to cell membrane repair.