Open AccessPhenotypic Frailty Assessment in Mice: Development, Discoveries, and Experimental Considerations
Author(s) -
Cory W. Baumann,
Dongmin Kwak,
LaDora V. Thompson
Publication year - 2020
Publication title -
physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.14
H-Index - 125
eISSN - 1548-9213
pISSN - 1548-9221
DOI - 10.1152/physiol.00016.2020
Subject(s) - phenotype , biology , lethality , gerontology , bioinformatics , medicine , computational biology , genetics , gene
The underlying mechanisms contributing to the onset of frailty, its progression, and its mortality risk remain unknown. Recently, the two most common human frailty assessments were reverse-translated to mice. Here, we highlight the development of the mouse frailty phenotype, unique discoveries, experimental considerations, and future perspectives.