Open AccessGut Microbiota in Liver Disease: What Do We Know and What Do We Not Know?
Author(s) -
Lu Jiang,
Bernd Schnabl
Publication year - 2020
Publication title -
physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.14
H-Index - 125
eISSN - 1548-9213
pISSN - 1548-9221
DOI - 10.1152/physiol.00005.2020
Subject(s) - fatty liver , steatohepatitis , gut flora , liver disease , disease , pathogenesis , medicine , chronic liver disease , gastroenterology , biology , immunology , cirrhosis
The gut and the liver have a bidirectional communication via the biliary system and the portal vein. The intestinal microbiota and microbial products play an important role for modulating liver diseases such as alcohol-associated liver disease, non-alcoholic fatty liver disease and steatohepatitis, and cholestatic liver diseases. Here, we review the role of the gut microbiota and its products for the pathogenesis and therapy of chronic liver diseases.