Open AccessGut Microbial Metabolites and Blood Pressure Regulation: Focus on SCFAs and TMAO
Author(s) -
Brian G. Poll,
Muhammad Umar Cheema,
Jennifer L. Pluznick
Publication year - 2020
Publication title -
physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.14
H-Index - 125
eISSN - 1548-9213
pISSN - 1548-9221
DOI - 10.1152/physiol.00004.2020
Subject(s) - gut microbiome , gut flora , microbiome , metabolite , trimethylamine n oxide , trimethylamine , microbial metabolism , biology , biochemistry , microbiology and biotechnology , chemistry , bacteria , bioinformatics , genetics
Shifts in the gut microbiome play a key role in blood pressure regulation, and changes in the production of gut microbial metabolites are likely to be a key mechanism. Known gut microbial metabolites include short-chain fatty acids, which can signal via G-protein-coupled receptors, and trimethylamine-N oxide. In this review, we provide an overview of gut microbial metabolites documented thus far to play a role in blood pressure regulation.