Open AccessDifferent sensitivity of action potential generation to the rate of depolarization in vagal afferent A-fiber versus C-fiber neurons
Author(s) -
Hui Sun
Publication year - 2021
Publication title -
journal of neurophysiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.302
H-Index - 245
eISSN - 1522-1598
pISSN - 0022-3077
DOI - 10.1152/jn.00722.2020
Subject(s) - depolarization , neuroscience , afferent , membrane potential , chemistry , electrophysiology , fiber , sensory system , biophysics , biology , organic chemistry
This study demonstrates that the action potential discharge in vagal afferent A-fiber neurons is about 20 times more sensitive to the rate of membrane depolarization compared to C-fiber neurons. The sensitivity of action potential generation to the depolarization rate in vagal sensory neurons is independent of the intensity of current stimuli but nearly abrogated by inhibiting the D-type potassium channel. These findings help better understand the mechanisms that control the activation of vagal afferent nerves.