Open AccessFunctional subgroups of cochlear inner hair cell ribbon synapses differently modulate their EPSC properties in response to stimulation
Author(s) -
Mamiko Niwa,
Eric D. Young,
Elisabeth Glowatzki,
Anthony J. Ricci
Publication year - 2021
Publication title -
journal of neurophysiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.302
H-Index - 245
eISSN - 1522-1598
pISSN - 0022-3077
DOI - 10.1152/jn.00452.2020
Subject(s) - synapse , excitatory postsynaptic potential , ribbon synapse , neuroscience , postsynaptic potential , spiral ganglion , stimulation , postsynaptic current , neurotransmission , hair cell , chemistry , inhibitory postsynaptic potential , biology , cochlea , synaptic vesicle , receptor , biochemistry , vesicle , membrane
Data presented here provide the first direct functional evidence of late synaptic maturation of the hair cell- spiral ganglion neuron synapse, where pillar synapses mature after postnatal day 20. Data identify a presynaptic difference in release during stimulation. This difference may in part drive afferent firing properties.