Open AccessLoneliness is linked to specific subregional alterations in hippocampus-default network covariation
Author(s) -
Chris Zajner,
R. Nathan Spreng,
Danilo Bzdok
Publication year - 2021
Publication title -
journal of neurophysiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.302
H-Index - 245
eISSN - 1522-1598
pISSN - 0022-3077
DOI - 10.1152/jn.00339.2021
Subject(s) - hippocampus , neuroscience , loneliness , psychology , default mode network , population , functional connectivity , medicine , social psychology , environmental health
The hippocampus and default network have been implicated in rich social interaction. Yet, these allocortical and neocortical neural systems have been interrogated in mostly separate literatures. Here, we conjointly investigate the hippocampus and default network at a subregion level, by capitalizing structural brain scans from ∼40,000 participants. We thus reveal unique insights on the nature of the “lonely brain” by estimating the regimes of covariation between the hippocampus and default network at population scale.