Persistent and resurgent Na+ currents in vestibular calyx afferents | Zendy

Frances L. Meredith | Zendy; Katherine J. Rennie | Zendy

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Persistent and resurgent Na⁺ currents in vestibular calyx afferents

Author(s) -

Frances L. Meredith,

Katherine J. Rennie

Publication year - 2020

Publication title -

journal of neurophysiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.302

H-Index - 245

eISSN - 1522-1598

pISSN - 0022-3077

DOI - 10.1152/jn.00124.2020

Subject(s) - vestibular system , calyx , neuroscience , vestibular nerve , afferent , electrophysiology , scarpa's ganglion , vestibular nuclei , chemistry , anatomy , biology , physics

Action potential firing patterns differ between groups of afferent neurons innervating vestibular epithelia. We investigated the biophysical properties of Na + currents in specialized vestibular calyx afferent terminals during postnatal development. Mature calyces express Na + currents with transient, persistent, and resurgent components. Nav1.6 channels contribute to resurgent Na + currents and may enhance firing in peripheral calyx afferents. Understanding Na + channels that contribute to vestibular nerve responses has implications for developing new treatments for vestibular dysfunction.

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