Open AccessLeucine augments specific skeletal muscle mitochondrial respiratory pathways during recovery following 7 days of physical inactivity in older adults
Author(s) -
Emily ArentsonLantz,
Jasmine Mikovic,
Nisha Bhattarai,
Christopher S. Fry,
Séverine Lamon,
Craig Porter,
Douglas PaddonJones
Publication year - 2021
Publication title -
journal of applied physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.253
H-Index - 229
eISSN - 8750-7587
pISSN - 1522-1601
DOI - 10.1152/japplphysiol.00810.2020
Subject(s) - skeletal muscle , leucine , respiration , oxidative stress , endocrinology , mitochondrion , respiratory system , medicine , sarcopenia , insulin sensitivity , biology , diabetes mellitus , anatomy , insulin resistance , biochemistry , amino acid
In older adults, leucine mitigated the loss of insulin sensitivity associated with muscular disuse. Leucine supplementation increased mitochondrial respiration and reduced a marker of oxidative stress following periods of disuse and rehabilitation.