Open AccessThe cardioprotective effect persisting during recovery from cold acclimation is mediated by the β2-adrenoceptor pathway and Akt activation
Author(s) -
Veronika Tibenská,
Aneta Marvanova,
Barbara Elsnicová,
Lucie Hejnová,
Pavel Vebr,
Jiřı́ Novotný,
František Kolář,
Olga Nováková,
Jitka Žurmanová
Publication year - 2021
Publication title -
journal of applied physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.253
H-Index - 229
eISSN - 8750-7587
pISSN - 1522-1601
DOI - 10.1152/japplphysiol.00756.2020
Subject(s) - acclimatization , cardioprotection , protein kinase b , limiting , biology , medicine , chemistry , endocrinology , pharmacology , signal transduction , microbiology and biotechnology , ischemia , mechanical engineering , engineering , botany
Cardioprotective effect of cold acclimation and that persisting for 2 wk after recovery engage in different mechanisms. The β 2 -adrenoceptor/G i pathway and Akt are involved only in the mechanism of infarct size-limiting effect occurring during the recovery phase. GSK-3β translocated from the Z-line to the H-zone of sarcomeres by cold acclimation returns back to the original position after the recovery phase. The results provide new insights potentially useful for the development of cardiac therapies.