Open AccessLong-term physical inactivity exacerbates hindlimb unloading-induced muscle atrophy in young rat soleus muscle
Author(s) -
Toshinori Yoshihara,
Toshiharu Natsume,
Takamasa Tsuzuki,
Shuo-wen Chang,
Ryo Kakigi,
Shuichi Machida,
Takao Sugiura,
Hisashi Naito
Publication year - 2021
Publication title -
journal of applied physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.253
H-Index - 229
eISSN - 8750-7587
pISSN - 1522-1601
DOI - 10.1152/japplphysiol.00494.2020
Subject(s) - hindlimb , soleus muscle , downregulation and upregulation , muscle atrophy , atrophy , endocrinology , medicine , oxidative stress , ubiquitin , chemistry , skeletal muscle , biology , biochemistry , gene
NEW & NOTEWORTHY: Long-term physical inactivity exacerbates hindlimb unloading-induced disuse muscle atrophy in young rat soleus muscles, possibly mediated by oxidative stress-induced protein ubiquitination via HDAC4- and NF-κB p65-induced MuRF1 mRNA upregulation.