Open AccessPostexercise urinary alpha-1 acid glycoprotein is not dependent on hypoxia
Author(s) -
Kelsey E. Joyce,
George M. Balanos,
Christopher Bradley,
Amy Fountain,
Arthur R. Bradwell,
Samuel J. E. Lucas
Publication year - 2022
Publication title -
journal of applied physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.253
H-Index - 229
eISSN - 8750-7587
pISSN - 1522-1601
DOI - 10.1152/japplphysiol.00476.2021
Subject(s) - medicine , hypoxemia , endocrinology , hypoxia (environmental) , excretion , vo2 max , urinary system , albumin , heart rate , physical exercise , proteinuria , chemistry , blood pressure , kidney , oxygen , organic chemistry
By superimposing hypoxic exposure and maximal exercise, we were able to investigate the impact of hypoxia on postexercise proteinuria. Urinalysis for α1-AGP (via particle-enhanced immunoturbidimetry) in specimens collected pre-/postexercise enabled the sensitive detection of altered glomerular permeability. Data indicated that exercise intensity, rather than the degree of exercise-induced hypoxemia, determines postexercise proteinuria.