Open AccessEffect of an exercise bout before the booster dose of an inactivated SARS-CoV-2 vaccine on immunogenicity in immunocompromised patients
Author(s) -
Bruno Gualano,
Carla G. S. Saad,
Sofia Mendes Sieczkowska,
Ítalo Ribeiro Lemes,
Rafael Pires da Silva,
Ana Jéssica Pinto,
Bruna Caruso Mazzolani,
Fabiana Infante Smaira,
Saulo Gil,
Gersiel Nascimento de Oliveira Júnior,
Nádia Emi Aikawa,
Ana Cristina Medeiros-Ribeiro,
Clóvis A. Silva,
Emily Figueiredo Neves Yuki,
Sandra Gofinet Pasoto,
Rosa Maria Rodrigues Pereira,
Samuel Katsuyuki Shinjo,
Danieli Andrade,
Percival Degrava Sampaio-Barros,
Hamilton Roschel,
Eloísa Bonfá
Publication year - 2022
Publication title -
journal of applied physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.253
H-Index - 229
eISSN - 8750-7587
pISSN - 1522-1601
DOI - 10.1152/japplphysiol.00015.2022
Subject(s) - immunogenicity , medicine , booster (rocketry) , booster dose , vaccination , titer , serology , immunology , antibody , physics , astronomy
This randomized controlled study aimed to investigate whether a single bout of exercise before the homologous booster dose of a SARS-CoV-2 inactivated vaccine could enhance immunogenicity in patients with spondyloarthritis. We selected 60 consecutive patients with spondyloarthritis (SpA). Patients assigned to the intervention group performed an exercise bout comprising three exercises. Then, they remained at rest for 1 h before vaccination. The control group remained at rest before vaccination. Immunogenicity was assessed before (Pre) and 1 mo after (Post) the booster using seropositivity rates of total anti-SARS-CoV-2 S1/S2 IgG, geometric mean titers of anti-S1/S2 IgG (GMT), frequency of neutralizing antibodies (NAb) positivity, and NAb activity. At Pre, 16 patients from the exercise group and 16 patients from the control group exhibited seropositivity for IgG (59% vs. 57.1%), and 1 mo after the booster dose, seropositivity occurred in 96% versus 100% of the cases. Only 10 patients from the exercise group and 12 patients from the control group showed positive NAb serology at Pre (37% vs. 42.8%). One month following the booster, NAb positivity was 96% versus 93%. GMT was comparable between groups at Pre. At Post, GMT increased similarly in both groups. Likewise, NAb activity was similar between groups at Pre and increased similarly in both of them as a result of the booster (47.5% vs. 39.9%). In conclusion, a single bout of exercise did not enhance immunogenicity to a homologous booster dose of an inactivated SARS-CoV-2 vaccine among patients with spondyloarthritis. NEW & NOTEWORTHY We tested the role of exercise as an adjuvant to a booster of a COVID-19 vaccine. Immunocompromised patients were immunized after an acute bout of exercise or not. Patients exhibited an excellent immunogenicity in response to the booster dose. Exercise did not add to the vaccine effects on IgG or neutralizing antibodies.