Open AccessZebrafish (Danio rerio) larva as an in vivo vertebrate model to study renal function
Author(s) -
Jan Stephan Bolten,
Anna Pratsinis,
Claudio Luca Alter,
Gert Fricker,
Jörg Huwyler
Publication year - 2022
Publication title -
american journal of physiology. renal physiology./american journal of physiology. renal physiology
Language(s) - English
Resource type - Journals
eISSN - 1931-857X
pISSN - 1522-1466
DOI - 10.1152/ajprenal.00375.2021
Subject(s) - danio , zebrafish , in vivo , in vitro , renal function , biology , function (biology) , computational biology , vertebrate , larva , microbiology and biotechnology , endocrinology , genetics , gene , ecology
The study of renal function remains a challenge. In vitro cell-based assays are approved to study, e.g., ABC/SLC-mediated drug transport but do not cover other renal functions as glomerular filtration. Here, in vivo studies combined with in vitro assays are needed, which are time consuming and expensive. In view of these limitations, our proof-of-concept study demonstrates that the zebrafish larva is a translational in vivo test model that includes mechanistic investigations to study renal function.