Open AccessG protein-coupled estrogen receptor 1 as a novel regulator of blood pressure
Author(s) -
Eman Y. Gohar
Publication year - 2020
Publication title -
american journal of physiology. renal physiology./american journal of physiology. renal physiology
Language(s) - English
Resource type - Journals
eISSN - 1931-857X
pISSN - 1522-1466
DOI - 10.1152/ajprenal.00045.2020
Subject(s) - regulator , estrogen , estrogen receptor , blood pressure , medicine , receptor , endocrinology , bioinformatics , biology , neuroscience , breast cancer , biochemistry , cancer , gene
The mechanisms underlying hypertension are multifaceted and incompletely understood. New evidence suggests that G protein-coupled estrogen receptor 1 (GPER1) mediates protective actions within the cardiovascular and renal systems. This mini-review focuses on recent advancements in our understanding of the vascular, renal, and cardiac GPER1-mediated mechanisms that influence blood pressure regulation. We emphasize clinical and basic evidence that suggests GPER1 as a novel target to aid therapeutic strategies for hypertension. Furthermore, we discuss current controversies and challenges facing GPER1-related research.