Open AccessThe complex role of prostaglandin E2-EP receptor signaling in wound healing
Author(s) -
Kristy E. Gilman,
Kirsten H. Limesand
Publication year - 2021
Publication title -
american journal of physiology. regulatory, integrative and comparative physiology/american journal of physiology. regulatory, integrative, and comparative physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.266
H-Index - 175
eISSN - 1522-1490
pISSN - 0363-6119
DOI - 10.1152/ajpregu.00185.2020
Subject(s) - wound healing , receptor , prostaglandin e2 receptor , signal transduction , microbiology and biotechnology , lipid signaling , prostaglandin e2 , prostaglandin , chemistry , biology , biochemistry , endocrinology , immunology , agonist
Prostaglandins are critical lipid mediators involved in the wound healing response, with prostaglandin E 2 (PGE 2 ) being the most complex and exhibiting the most diverse physiological outputs. PGE 2 signals via four G protein-coupled receptors, termed EP-receptors 1-4 that induce distinct signaling pathways upon activation and lead to an array of different outputs. Recent studies examining the role of PGE 2 and EP receptor signaling in wound healing following various forms of tissue damage are discussed in this review.