The complex role of prostaglandin E2-EP receptor signaling in wound healing | Zendy

Kristy E. Gilman | Zendy; Kirsten H. Limesand | Zendy

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The complex role of prostaglandin E₂-EP receptor signaling in wound healing

Author(s) -

Kristy E. Gilman,

Kirsten H. Limesand

Publication year - 2020

Publication title -

ajp regulatory integrative and comparative physiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.266

H-Index - 175

eISSN - 1522-1490

pISSN - 0363-6119

DOI - 10.1152/ajpregu.00185.2020

Subject(s) - wound healing , receptor , prostaglandin e2 receptor , signal transduction , microbiology and biotechnology , lipid signaling , prostaglandin e2 , prostaglandin , chemistry , biology , biochemistry , endocrinology , immunology , agonist

Prostaglandins are critical lipid mediators involved in the wound healing response, with prostaglandin E 2 (PGE 2 ) being the most complex and exhibiting the most diverse physiological outputs. PGE 2 signals via four G protein-coupled receptors, termed EP-receptors 1-4 that induce distinct signaling pathways upon activation and lead to an array of different outputs. Recent studies examining the role of PGE 2 and EP receptor signaling in wound healing following various forms of tissue damage are discussed in this review.

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