Open AccessFine particulate matter (PM2.5) inhalation-induced alterations in the plasma lipidome as promoters of vascular inflammation and insulin resistance
Author(s) -
Bradford G. Hill,
Benjamin Rood,
Amanda Ribble,
Petra Haberzettl
Publication year - 2021
Publication title -
american journal of physiology. heart and circulatory physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.524
H-Index - 197
eISSN - 1522-1539
pISSN - 0363-6135
DOI - 10.1152/ajpheart.00881.2020
Subject(s) - lipidome , inflammation , oxidative stress , insulin resistance , medicine , endocrinology , chemistry , endothelial dysfunction , homeostasis , insulin , biology , lipid metabolism
We found that circulating plasma constituents are responsible for air pollution-induced vascular pathologies. Inhalation of fine particulate matter (≤PM 2.5 ) promotes a unique form of dyslipidemia that manifests in a manner dependent upon pulmonary oxidative stress. The air pollution-engendered dyslipidemic phenotype is characterized by elevated free fatty acid species and diminished phospholipid species, which could contribute to vascular inflammation and loss of insulin sensitivity.