Open AccessFaster skin wound healing predicts survival after myocardial infarction
Author(s) -
Mediha BecirovicAgic,
Upendra Chalise,
Mira Jung,
Jocelyn R. RodriguezPaar,
Shelby R. Konfrst,
Elizabeth R. Flynn,
Jeffrey Salomon,
Michael E. Hall,
Merry L. Lindsey
Publication year - 2022
Publication title -
american journal of physiology. heart and circulatory physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.524
H-Index - 197
eISSN - 1522-1539
pISSN - 0363-6135
DOI - 10.1152/ajpheart.00612.2021
Subject(s) - medicine , wound healing , myocardial infarction , inflammation , cardiology , coronary artery disease , surgery
Faster skin wound healers had more efficient cardiac healing after myocardial infarction (MI). Two plasma proteins at D3 MI, EAF1 and A2M, predicted MI death in 66% of cases. ApoD regulated both skin and cardiac wound healing in male mice by promoting inflammation. The skin was a mirror to the heart and common pathways linked wound healing across organs.