
Dysregulated micro-RNAs and long noncoding RNAs in cardiac development and pediatric heart failure
Author(s) -
Lee S. Toni,
Frehiwet T. Hailu,
Carmen C. Sucharov
Publication year - 2020
Publication title -
american journal of physiology. heart and circulatory physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.524
H-Index - 197
eISSN - 1522-1539
pISSN - 0363-6135
DOI - 10.1152/ajpheart.00511.2019
Subject(s) - non coding rna , long non coding rna , microrna , context (archaeology) , rna , biology , disease , heart failure , computational biology , gene , gene expression , heart development , bioinformatics , medicine , genetics , pathology , paleontology , embryonic stem cell
Noncoding RNAs (ncRNAs) are broadly described as RNA molecules that are not translated into protein. The investigation of dysregulated ncRNAs in human diseases such as cancer, neurological, and cardiovascular diseases has been under way for well over a decade. Micro-RNAs and long noncoding RNAs (lncRNAs) are the best characterized ncRNAs. These ncRNAs can have profound effects on the regulation of gene expression during cardiac development and disease. Importantly, ncRNAs are significant regulators of gene expression in several congenital heart diseases and can positively or negatively impact cardiovascular development. In this review, we focus on literature involving micro-RNAs and lncRNAs in the context of pediatric cardiovascular diseases, preclinical models of heart failure, and cardiac development.