Dysregulated micro-RNAs and long noncoding RNAs in cardiac development and pediatric heart failure | Zendy

Lee S. Toni | Zendy; Frehiwet Hailu | Zendy; Carmen C. Sucharov | Zendy

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Dysregulated micro-RNAs and long noncoding RNAs in cardiac development and pediatric heart failure

Author(s) -

Lee S. Toni,

Frehiwet Hailu,

Carmen C. Sucharov

Publication year - 2020

Publication title -

ajp heart and circulatory physiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.524

H-Index - 197

eISSN - 1522-1539

pISSN - 0363-6135

DOI - 10.1152/ajpheart.00511.2019

Subject(s) - long non coding rna , non coding rna , context (archaeology) , microrna , rna , biology , heart failure , disease , gene , bioinformatics , computational biology , gene expression , medicine , genetics , pathology , paleontology

Noncoding RNAs (ncRNAs) are broadly described as RNA molecules that are not translated into protein. The investigation of dysregulated ncRNAs in human diseases such as cancer, neurological, and cardiovascular diseases has been under way for well over a decade. Micro-RNAs and long noncoding RNAs (lncRNAs) are the best characterized ncRNAs. These ncRNAs can have profound effects on the regulation of gene expression during cardiac development and disease. Importantly, ncRNAs are significant regulators of gene expression in several congenital heart diseases and can positively or negatively impact cardiovascular development. In this review, we focus on literature involving micro-RNAs and lncRNAs in the context of pediatric cardiovascular diseases, preclinical models of heart failure, and cardiac development.

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