Open AccessAdropin: a hepatokine modulator of vascular function and cardiac fuel metabolism
Author(s) -
Bellina Mushala,
Iain Scott
Publication year - 2021
Publication title -
american journal of physiology. heart and circulatory physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.524
H-Index - 197
eISSN - 1522-1539
pISSN - 0363-6135
DOI - 10.1152/ajpheart.00449.2020
Subject(s) - function (biology) , hormone , biology , neuroscience , microbiology and biotechnology , homeostasis , signal transduction , metabolism , bioinformatics , endocrinology
Adropin is a nutritionally regulated peptide hormone, secreted primarily by the liver, which modulates metabolic homeostasis in a number of tissues. Growing evidence suggests that adropin is an important regulatory component in a number of cardiovascular pathologies, and may be central to the control of cardiac fuel metabolism and vascular function. In this mini-review, we examine the known facets of adropin biology, discuss open questions in the field, and speculate on the therapeutic potential of targeting adropin-related signaling pathways in cardiovascular diseases.