Open AccessCarotid intima-media thickness and flow-mediated dilation do not predict acute in-hospital outcomes in patients hospitalized with COVID-19
Author(s) -
Michelle Cristina-Oliveira,
Kamila Meireles,
Saulo Gil,
Fábio Cavalcante de Assis,
João Carlos Geber Júnior,
Samuel Katsuyuki Shinjo,
Heraldo Possolo de Souza,
Alfredo Nicodemos Cruz Santana,
Paul Swinton,
Luciano F. Drager,
Bruno Gualano,
Hamilton Roschel,
Tiago Peçanha
Publication year - 2022
Publication title -
american journal of physiology. heart and circulatory physiology
Language(s) - English
Resource type - Journals
eISSN - 1522-1539
pISSN - 0363-6135
DOI - 10.1152/ajpheart.00026.2022
Subject(s) - medicine , confounding , odds ratio , mechanical ventilation , confidence interval , logistic regression , univariate analysis , intensive care unit , covid-19 , intima media thickness , cardiology , multivariate analysis , disease , carotid arteries , infectious disease (medical specialty)
Studies have suggested a role of endothelial dysfunction and atherosclerosis in COVID-19 pathophysiology. In this prospective cohort study, we assessed the prognostic value of carotid intima-media thickness (IMT) and flow-mediated dilation (FMD) in patients with COVID-19. Carotid IMT and FMD were not independent predictors of major outcomes. These results suggest that other risk factors may be the main drivers of clinical outcomes in patients with COVID-19.