Nr4A1 modulates inflammation-associated intestinal fibrosis and dampens fibrogenic signaling in myofibroblasts | Zendy

Vivek Krishna Pulakazhi Venu | Zendy; Laurie Alston | Zendy; Mircea Iftinca | Zendy; Yi-Cheng Tsai | Zendy; Matthew Stephens | Zendy; Vineetha Warriyar K. V. | Zendy; Sonia Rehal | Zendy; Grace Hudson | Zendy; Holly Szczepanski | Zendy; PierreYves von der Weid | Zendy; Christophe Altier | Zendy; Simon A. Hirota | Zendy

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Nr4A1 modulates inflammation-associated intestinal fibrosis and dampens fibrogenic signaling in myofibroblasts

Author(s) -

Vivek Krishna Pulakazhi Venu,

Laurie Alston,

Mircea Iftinca,

Yi-Cheng Tsai,

Matthew Stephens,

Vineetha Warriyar K. V.,

Sonia Rehal,

Grace Hudson,

Holly Szczepanski,

PierreYves von der Weid,

Christophe Altier,

Simon A. Hirota

Publication year - 2021

Publication title -

ajp gastrointestinal and liver physiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.644

H-Index - 169

eISSN - 1522-1547

pISSN - 0193-1857

DOI - 10.1152/ajpgi.00338.2019

Subject(s) - fibrosis , medicine , myofibroblast , inflammation , thickening , inflammatory bowel disease , complication , gastroenterology , downregulation and upregulation , disease , pathology , biology , biochemistry , chemistry , polymer science , gene

Fibrosis and increased muscle thickening contribute to stricture formation and intestinal obstruction, a complication that occurs in 30%–50% of patients with CD within 10 yr of disease onset. More than 50% of those who undergo surgery to remove the obstructed bowel will experience stricture recurrence. To date, there are no drug-based approaches approved to treat intestinal strictures. In the current submission, we identify NR4A1 as a novel target to treat inflammation-associated intestinal fibrosis.

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