Open AccessNRG4-ErbB4 signaling represses proinflammatory macrophage activity
Author(s) -
Michael A. Schumacher,
Isabella Dennis,
Cambrian Y. Liu,
Cache Robinson,
Judie Shang,
Jessica K. Bernard,
M. Kay Washington,
D. Brent Polk,
Mark R. Frey
Publication year - 2021
Publication title -
american journal of physiology. gastrointestinal and liver physiology/american journal of physiology: gastrointestinal and liver physiology
Language(s) - English
Resource type - Journals
eISSN - 1522-1547
pISSN - 0193-1857
DOI - 10.1152/ajpgi.00296.2020
Subject(s) - proinflammatory cytokine , macrophage , erbb4 , inflammation , microbiology and biotechnology , signal transduction , cancer research , immunology , medicine , chemistry , biology , in vitro , biochemistry , receptor tyrosine kinase
Proinflammatory macrophages are essential drivers of colitis and express the growth factor receptor ErbB4. This study tested the role of ErbB4 and its specific ligand, NRG4, in regulating macrophage function. We show that endogenous NRG4-ErbB4 signaling limits macrophage production of proinflammatory cytokines in vitro and limits colitis severity in vivo and thus is a potential target for therapeutic intervention.