Open AccessEstradiol and RSPO3 regulate vertebral trabecular bone mass independent of each other
Author(s) -
Karin Nilsson,
Jianyao Wu,
Kristian Gustafsson,
Maha El Shahawy,
Antti Koskela,
Juha Tuukkanen,
Jan Tuckermann,
Petra Henning,
Ulf H. Lerner,
Claes Ohlsson,
Sofia MovérareSkrtic
Publication year - 2022
Publication title -
endocrinology and metabolism/american journal of physiology: endocrinology and metabolism
Language(s) - English
Resource type - Journals
eISSN - 1522-1555
pISSN - 0193-1849
DOI - 10.1152/ajpendo.00383.2021
Subject(s) - ovariectomized rat , osteoblast , endocrinology , osteoporosis , medicine , estrogen , runx2 , trabecular bone , cortical bone , bone density , chemistry , anatomy , in vitro , biochemistry
Osteoblast-derived RSPO3 is known to be a crucial regulator of vertebral trabecular bone. Our new findings show that RSPO3 and estrogen regulate trabecular bone independent of each other, but that RSPO3 is necessary for a complete estrogenic effect on cortical bone.