Open AccessExtracellular flux analyses reveal differences in mitochondrial PBMC metabolism between high-fit and low-fit females
Author(s) -
Joëlle J. E. Janssen,
Bart Lagerwaard,
Mojtaba Porbahaie,
Arie G. Nieuwenhuizen,
H.F.J. Savelkoul,
R. J. Joost van Neerven,
Jaap Keijer,
Vincent C.J. de Boer
Publication year - 2022
Publication title -
endocrinology and metabolism/american journal of physiology: endocrinology and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.507
H-Index - 201
eISSN - 1522-1555
pISSN - 0193-1849
DOI - 10.1152/ajpendo.00365.2021
Subject(s) - peripheral blood mononuclear cell , basal metabolic rate , medicine , metabolism , endocrinology , extracellular , glycolysis , biology , chemistry , andrology , immunology , biochemistry , in vitro
Mitochondrial metabolism was significantly higher in PBMCs from high-fit than from low-fit females. This was unrelated to PBMC composition and not impacted by a recent bout of exercise. Our study reveals a link between PBMC metabolism and levels of aerobic fitness, increasing the relevance of PBMC metabolism as a marker to study the impact of lifestyle factors on human health.