Open AccessThermogenic recruitment of brown and brite/beige adipose tissues is not obligatorily associated with macrophage accretion or attrition
Author(s) -
Nathalie Boulet,
Ineke Luijten,
Barbara Can,
Jan Nedergaard
Publication year - 2021
Publication title -
endocrinology and metabolism/american journal of physiology: endocrinology and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.507
H-Index - 201
eISSN - 1522-1555
pISSN - 0193-1849
DOI - 10.1152/ajpendo.00352.2020
Subject(s) - adipose tissue , proinflammatory cytokine , macrophage , white adipose tissue , adipose tissue macrophages , accretion (finance) , endocrinology , microbiology and biotechnology , medicine , biology , inflammation , chemistry , genetics , physics , astrophysics , in vitro
A regulatory or mediatory role—positive or negative—for macrophages in the recruitment of brown adipose tissue is presently discussed. As the recruited state in the tissue is a dynamic process, maintenance of the recruited state would need persistent alterations in macrophage complement. Contrary to this expectation, we demonstrate here an absence of alterations in macrophage complement in thermogenically recruited brown—or brite/beige—adipose tissues. Macrophage regulation of thermogenic capacity is thus less likely.