Open AccessDuodenal mucosal resurfacing with a GLP-1 receptor agonist increases postprandial unconjugated bile acids in patients with insulin-dependent type 2 diabetes
Author(s) -
Suzanne Meiring,
Emma C. E. Meessen,
Annieke C.G. van Baar,
F. Holleman,
Max Nieuwdorp,
Steven W. M. Olde Damink,
Frank G. Schaap,
Fred M. Vaz,
Albert K. Groen,
Maarten R. Soeters,
Jacques J.G.H.M. Bergman
Publication year - 2022
Publication title -
endocrinology and metabolism/american journal of physiology: endocrinology and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.507
H-Index - 201
eISSN - 1522-1555
pISSN - 0193-1849
DOI - 10.1152/ajpendo.00337.2021
Subject(s) - postprandial , fgf19 , medicine , bile acid , endocrinology , farnesoid x receptor , g protein coupled bile acid receptor , insulin , type 2 diabetes , insulin resistance , glycemic , chemistry , diabetes mellitus , receptor , biochemistry , nuclear receptor , fibroblast growth factor , transcription factor , gene
Glycemic and metabolic improvements are seen in patients with type 2 diabetes after replacing their insulin therapy with DMR and GLP-1. These changes are accompanied by changes in postprandial bile acid concentrations: increased unconjugated and secondary bile acids.