Open AccessMuscle damaging eccentric exercise attenuates disuse-induced declines in daily myofibrillar protein synthesis and transiently prevents muscle atrophy in healthy men
Author(s) -
Tom S O Jameson,
Sean P. Kilroe,
Jonathan Fulford,
Doaa R. Abdelrahman,
Andrew J. Murton,
Marlou L. Dirks,
Francis B. Stephens,
Benjamin T. Wall
Publication year - 2021
Publication title -
endocrinology and metabolism/american journal of physiology: endocrinology and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.507
H-Index - 201
eISSN - 1522-1555
pISSN - 0193-1849
DOI - 10.1152/ajpendo.00294.2021
Subject(s) - myofibril , atrophy , eccentric , muscle atrophy , muscle protein , endocrinology , medicine , eccentric exercise , muscle hypertrophy , skeletal muscle , muscle damage , physics , quantum mechanics
We investigated the impact of prior muscle-damaging eccentric exercise on disuse-induced muscle deconditioning. Two and 7 days of muscle disuse per se lowered quadriceps muscle volume in association with lowered daily myofibrillar protein synthesis (MyoPS). Prior eccentric exercise prevented the decline in muscle volume after 2 days and attenuated the decline in MyoPS after 2 and 7 days. These data indicate eccentric exercise increases MyoPS and transiently prevents quadriceps muscle atrophy during muscle disuse.