Open AccessIntermittent bolus feeding does not enhance protein synthesis, myonuclear accretion, or lean growth more than continuous feeding in a premature piglet model
Author(s) -
Marko Rudar,
Jane Naberhuis,
Agus Suryawan,
Hanh Nguyen,
Barbara J. Stoll,
Candace C. Style,
Mariatu A. Verla,
Oluyinka O. Olutoye,
Douglas G. Burrin,
Marta L. Fiorotto,
Teresa A. Davis
Publication year - 2021
Publication title -
endocrinology and metabolism/american journal of physiology: endocrinology and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.507
H-Index - 201
eISSN - 1522-1555
pISSN - 0193-1849
DOI - 10.1152/ajpendo.00236.2021
Subject(s) - anabolism , bolus (digestion) , zoology , lean body mass , parenteral nutrition , medicine , endocrinology , biology , chemistry , body weight
Extrauterine growth restriction often occurs in premature infants but may be mitigated by optimizing enteral feeding strategies. We show that intermittent bolus feeding does not increase skeletal muscle protein synthesis, myonuclear accretion, or lean growth more than continuous feeding in preterm pigs. This attenuated anabolic response of muscle to intermittent bolus feeding, compared with previous observations in pigs born at term, may contribute to deficits in lean mass that many premature infants exhibit into adulthood.