Open AccessBiological plausibility for interactions between dietary fat, resveratrol, ACE2, and SARS-CoV illness severity
Author(s) -
Justine Horne,
MarieClaude Vohl
Publication year - 2020
Publication title -
endocrinology and metabolism/american journal of physiology: endocrinology and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.507
H-Index - 201
eISSN - 1522-1555
pISSN - 0193-1849
DOI - 10.1152/ajpendo.00150.2020
Subject(s) - resveratrol , downregulation and upregulation , pathogenesis , receptor , covid-19 , angiotensin converting enzyme 2 , medicine , pharmacology , biology , endocrinology , gene , disease , genetics , infectious disease (medical specialty)
The angiotensin converting enzyme-2 (ACE2) cellular receptor is responsible for the pathogenesis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), thus impacting the entrance and clearance of the virus. Studies demonstrate that upregulation of ACE2 has a protective effect on SARS-CoV-2 illness severity. Moreover, animal studies demonstrate that dietary intake can modulate ACE2 gene expression and function. A high intake of resveratrol may have a protective role, upregulating ACE2 , whereas a high intake of dietary fat may have a detrimental role, downregulating ACE2 . As such, we postulate on the biological plausibility of interactions between dietary fat and/or resveratrol and ACE2 gene variations in the modulation of SARS-CoV-2 illness severity. We call to action the research community to test this plausible interaction in a sample of human subjects.