Open AccessCentral GLP-1 contributes to improved cognitive function and brain glucose uptake after duodenum-jejunum bypass on obese and diabetic rats
Author(s) -
Rexiati Ruze,
Qian Xu,
Guoqin Liu,
Yuekai Li,
Weijie Chen,
Zhiqiang Cheng,
Yuanyuan Xiong,
Shaozhuang Liu,
Guangyong Zhang,
Sanyuan Hu,
Zhibo Yan
Publication year - 2021
Publication title -
endocrinology and metabolism/american journal of physiology: endocrinology and metabolism
Language(s) - English
Resource type - Journals
eISSN - 1522-1555
pISSN - 0193-1849
DOI - 10.1152/ajpendo.00126.2021
Subject(s) - liraglutide , medicine , glucose transporter , glucose uptake , endocrinology , diabetes mellitus , glut4 , morris water navigation task , glucagon like peptide 1 , glucose homeostasis , duodenum , jejunum , insulin , hippocampus , insulin resistance , type 2 diabetes
The improvement of cognitive function following bariatric surgery has been highlighted while its mechanisms remain elusive. The brain glucose uptake of patients was improved after RYGB, and the DJB and sham surgery performed on obese and diabetic Wistar rats revealed that the elevated central GLP-1 contributes to the dramatic improvement of cognitive function, brain glucose uptake, transport, glucose sensing, and neuronal activation.