Open AccessDeficiency of arcuate nucleus kisspeptin results in postpubertal central hypogonadism
Author(s) -
Nimisha Nandankar,
Ariel L Negrón,
Andrew Wolfe,
Jon E. Levine,
Sally Radovick
Publication year - 2021
Publication title -
endocrinology and metabolism/american journal of physiology: endocrinology and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.507
H-Index - 201
eISSN - 1522-1555
pISSN - 0193-1849
DOI - 10.1152/ajpendo.00088.2021
Subject(s) - kisspeptin , arc (geometry) , arcuate nucleus , endocrinology , medicine , estrous cycle , conditional gene knockout , biology , hypothalamus , gene , phenotype , genetics , geometry , mathematics
We demonstrate through a novel, conditional knockout mouse model of arcuate nucleus (ARC)-specific kisspeptin in the KNDy neuron that ARC kisspeptin is critical for estrous cyclicity in female mice and GnRH/LH pulsatility in both sexes. Our study reveals that ARC kisspeptin is essential for normal gametogenesis, and the loss of ARC kisspeptin results in significant hypogonadism, impacting fertility status. Our findings further confirm that normal puberty occurs despite a loss of ARC kisspeptin.