Open AccessThe eIF4E-binding proteins are modifiers of cytoplasmic eIF4E relocalization during the heat shock response
Author(s) -
Rami Sukarieh,
Nahum Sonenberg,
Jerry Pelletier
Publication year - 2009
Publication title -
american journal of physiology. cell physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.432
H-Index - 181
eISSN - 1522-1563
pISSN - 0363-6143
DOI - 10.1152/ajpcell.00511.2008
Subject(s) - eif4e , translation (biology) , microbiology and biotechnology , heat shock protein , repressor , eukaryotic translation initiation factor 4 gamma , eukaryotic translation , protein biosynthesis , eukaryotic initiation factor , initiation factor , biology , messenger rna , genetics , transcription factor , gene
Stress granules (SGs) arise as a consequence of cellular stress, contain stalled translation preinitiation complexes, and are associated with cell survival during environmental insults. SGs are dynamic entities with proteins relocating into and out of them during stress. Among the repertoire of proteins present in SGs is eukaryotic initiation factor 4E (eIF4E), a translation factor required for cap-dependent translation and that regulates a rate-limiting step for protein synthesis. Herein, we demonstrate that localization of eIF4E to SGs is dependent on the presence of a family of repressor proteins, eIF4E-binding proteins (4E-BPs). Our results demonstrate that 4E-BPs regulate the SG localization of eIF4E.