Open AccessCardiac tissue remodeling in healthy aging: the road to pathology
Author(s) -
Evan Tracy,
Gabrielle Rowe,
Amanda J. LeBlanc
Publication year - 2020
Publication title -
american journal of physiology. cell physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.432
H-Index - 181
eISSN - 1522-1563
pISSN - 0363-6143
DOI - 10.1152/ajpcell.00021.2020
Subject(s) - contractility , extracellular matrix , ventricular remodeling , medicine , heart failure , pathophysiology , tissue remodeling , cardiology , fibrosis , pathology , biology , inflammation , microbiology and biotechnology
This review aims to highlight the normal physiological remodeling that occurs in healthy aging hearts, including changes that occur in contractility, conduction, valve function, large and small coronary vessels, and the extracellular matrix. These "normal" age-related changes serve as the foundation that supports decreased plasticity and limited ability for tissue remodeling during pathophysiological states such as myocardial ischemia and heart failure. This review will identify populations at greater risk for poor tissue remodeling in advanced age along with present and future therapeutic strategies that may ameliorate dysfunctional tissue remodeling in aging hearts.