Open AccessFirst Electrochemical Approach to Voltammetric Behavior and Sensing of Anticancer Drug Ponatinib
Author(s) -
Kamila Koszelska,
Witold Ciesielski,
Sylwia Smarzewska
Publication year - 2022
Publication title -
journal of the electrochemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.258
H-Index - 271
eISSN - 1945-7111
pISSN - 0013-4651
DOI - 10.1149/1945-7111/ac67f6
Subject(s) - cyclic voltammetry , electrochemistry , ponatinib , chemistry , detection limit , horizontal scan rate , voltammetry , analyte , electrode , square wave , analytical chemistry (journal) , chromatography , biochemistry , signal transduction , physics , dasatinib , tyrosine kinase , voltage , quantum mechanics
This study investigated for the first time the electrochemical behavior of the anticancer drug ponatinib (Pon). All voltammetric experiments were conducted using square-wave voltammetry (SWV) and cyclic voltammetry (CV), with a boron-doped diamond electrode (BDDE) as a working electrode. The recorded voltammograms showed a well-defined oxidation peak for Pon at a positive potential value of around +1.35 V in hydrochloric acid of pH 1.3. The study also analyzed the influence of experimental conditions, such as pH and composition of supporting electrolyte, as well as the parameters of the square-wave voltammetric technique. A rapid, simple, and sensitive SWV methodology was established for the determination of ponatinib in the concentration range of 1.0×10−6 − 2.0×10−5 molL−1, with a detection limit of 2.5×10−7 molL−1. The biological significance of the developed SWV procedure was demonstrated by a quantitative analysis of ponatinib in spiked urine samples with a highly satisfactory rate of recovery. In addition, the effect of some interfering agents coexisting in the human urine on the peak current of Pon was evaluated. Cyclic voltammetry was used to study the electrochemical behavior of the analyte. The obtained results indicated that the oxidation of ponatinib was an irreversible process and was controlled by diffusion.