Open AccessReview—Progress in Electroanalysis of p53, CEA, and CA19–9
Author(s) -
RuxandraMaria IlieMihai,
RalucaIoana Stefanvan Staden,
Jacobus Frederick van Staden
Publication year - 2022
Publication title -
journal of the electrochemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.258
H-Index - 271
eISSN - 1945-7111
pISSN - 0013-4651
DOI - 10.1149/1945-7111/ac5cea
Subject(s) - chronoamperometry , differential pulse voltammetry , biomarker , cyclic voltammetry , voltammetry , chemistry , analytical chemistry (journal) , electrochemistry , chromatography , electrode , biochemistry
Screening tests for panels of biomarkers such as the panel comprising p53, CEA, and CA19–9 facilitated early diagnosis of cancers and improvement of the quality of life. In this review, diverse electrochemical sensors used for the assay of p53, CEA, and CA 19–9 in biological samples are shown. Different methods of analysis such as differential pulse voltammetry, electrochemical impendance spectroscopy, chronoamperometry, and stochastic method were used for the assay of one biomarker (differential pulse voltammetry, chronoamperometry) or for the assay of a panel of biomarkers comprising p53, CA19–9, and CEA using stochastic method. The lowest limits of determination were obtained using the stochastic method; they were of fg ml −1 /fU ml −1 magnitude order.