Open AccessElectrochemical Enantioanalysis of D- and L-Cysteine with a Dual-Template Molecularly Imprinted Sensor
Author(s) -
Huipeng Hou,
Shanshan Tang,
Wei Wang,
Miao Liu,
Axin Liang,
Liquan Sun,
Aiqin Luo
Publication year - 2022
Publication title -
journal of the electrochemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.258
H-Index - 271
eISSN - 1945-7111
pISSN - 0013-4651
DOI - 10.1149/1945-7111/ac58c0
Subject(s) - molecularly imprinted polymer , differential pulse voltammetry , electrode , ionic liquid , molybdenum disulfide , electrochemical gas sensor , electrochemistry , materials science , chemistry , enantiomer , working electrode , analytical chemistry (journal) , cyclic voltammetry , chromatography , selectivity , organic chemistry , composite material , catalysis
The present work describes a faithful strategy of dual-template molecularly imprinted polymers (MIP) to chiral recognize and quantify D-Cystine (D-Cys) and L-Cystine (L-Cys) at ultra-trace level through “vector method.” Briefly, one has to saturate association D-Cys while analyzes L-Cys, and vice versa. Herein, the working electrode, magnetic glassy carbon (MGCE), was initially drop-coated with molybdenum disulfide-ionic liquid (MoS 2 -IL) dispersion liquid for large specific surface area and excellent electrical conductivity. After the working electrode was dried naturally, chitosan (CS) was electrodeposited on. And the strong electrostatic interactions between CS and Fe[(CN) 6 ] 3−/4− could further enhance the electric signal. Next, dual-template MIP dispersion liquid was drop-coated on the working electrode. Moreover, Fe 3 O 4 nano-particles (NPs) was regard as the support skeleton material of dual-template MIP, which could significantly improve the bonding strength with MGCE. Herein, the proposed sensor demonstrated good analytical figures of merits with Differential Pulse Voltammetry (DPV), showing that the LOD of L-Cys and D-Cys were 0.7402 pg ml −1 and 0.6136 pg ml −1 respectively, with linear response ranges from 1 pg ml −1 to 12 pg ml −1 for both enantiomers. Furthermore, the proposed sensor exhibited great potential in chiral recognition and biochemical analysis.